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Prosciutto and melon panini topped with hot honey, chile flakes and brie cheese in a cast iron skillet

Prosciutto and Melon Panini

Krista Stechman
The perfect combination of sweet, heat and salt. This panini has sweet melon, salty prosciutto, hot honey and creamy brie cheese combined with the fresh bite of basil. It's an amazing summer sandwich!
5 from 1 vote
Prep Time 10 mins
Cook Time 5 mins
Total Time 15 mins
Course dinner
Cuisine italian
Servings 4 people
Calories 598 kcal


Sandwich toppings

  • 16 oz cantaloupe cleaned and sliced
  • 7 oz herb and garlic brie cheese sliced
  • 4 oz prosciutto
  • ½ cup basil
  • 1 tbsp hot honey
  • ¼ tsp crushed red pepper


  • 8 slices panini bread round rustic Italian works as well

Pan Coating

  • 2 tbsp butter unsalted
  • 1 tbsp olive oil


Prepping the Toppings

  • Peel and de-seed the cantaloupe. Slice it into thin half moon shapes
  • Slice the brie cheese about ⅛ of an inch thick
    brie cheese sliced about 1/8 inch thick

Assemble the Panini

  • Layer brie cheese onto the bottom of the bread
  • Top the cheese with cantaloupe, prosciutto, basil, hot honey and crushed red pepper flakes
    panini bread layered with brie, cantaloupe, hot honey, basil, prosciutto and crushed red pepper
  • Add another layer of brie to the top of that and top each sandwich with the remaining slice of bread

Cooking the Paninis

  • Heat a cast iron, metal or non stick skillet and add the butter and oil
  • Once the butter and oil mix is hot then add the sandwiches. Let each side cook until it becomes a golden brown and the cheese is melted
    panini cooked in a cast iron skillet with melted brie pulling out
  • Serve immediately and ENJOY!


Brie cheese cuts easier when cold


Calories: 598kcalCarbohydrates: 36gProtein: 18gFat: 43gSaturated Fat: 21gPolyunsaturated Fat: 5gMonounsaturated Fat: 15gTrans Fat: 1gCholesterol: 69mgSodium: 677mgPotassium: 545mgFiber: 3gSugar: 26gVitamin A: 4347IUVitamin C: 42mgCalcium: 118mgIron: 2mg
Keyword cantaloupe, italian, melon, panini, prosciutto, summer sandwich, sweet and salty
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